Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia

DJ Ingle; RL Ambrose; SL Baines; S Duchene; A Gonçalves da Silva; DYJ Lee; M Jones; M Valcanis; G Taiaroa; SA Ballard; MD Kirk; BP Howden; JS Pearson; DA Williamson

Journal article

Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4,[5],12:i:- in Australia

DJ Ingle, RL Ambrose, SL Baines, S Duchene, A Gonçalves da Silva, DYJ Lee, M Jones, M Valcanis, G Taiaroa, SA Ballard, MD Kirk, BP Howden, JS Pearson, DA Williamson

Nature Communications | Published : 2021

DOI: 10.1038/s41467-021-25073-w

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Abstract

Salmonella enterica serovar 4,[5],12:i:- (Salmonella 4,[5],12:i:-) is a monophasic variant of Salmonella Typhimurium that has emerged as a global cause of multidrug resistant salmonellosis. We used Bayesian phylodynamics, genomic epidemiology, and phenotypic characterization to describe the emergence and evolution of Salmonella 4,[5],12:i:- in Australia. We show that the interruption of the genetic region surrounding the phase II flagellin, FljB, causing a monophasic phenotype, represents a stepwise evolutionary event through the accumulation of mobile resistance elements with minimal impairment to bacterial fitness. We identify three lineages with different population dynamics and discrete ..

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University of Melbourne Researchers

Danielle Ingle Author

Sarah Baines Author

Sebastian Duchene Garzon Author

George Taiaroa Author

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Grants

Awarded by Department of Health and Human Services, State Government of Victoria

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC), Australia Project Grant (APP1129770). D.J.I. is supported by an NHMRC Investigator Grant (APP1195210). S.D. was funded by the ARC (DE190100805). M.D.K. is supported by an NHMRC Career Development Fellowship (APP1145997). B.P.H. is supported by an NHMRC Investigator Grant (APP1196103). J.S.P. is supported by an NHMRC Career Development Fellowship (APP1159230). D.A.W. is supported by an NHMRC Investigator Grant (APP1174555). The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Department of Health and Human Services, Victoria.